Work

Clinical significance of IgE in a large cohort of patients with moderate or severe chronic graft‐versus‐host disease

Year: 2017

Type: article

Abstract: In summary, elevated IgE in cGVHD was associated with increased levels of multiple immune cell subsets and immunoglobulins suggesting that IgE may be a marker of more robust post-transplant immune reconstitution.Prior history of asthma was associated with elevated IgE, indicating that pre-transplant factors may still influence IgE even years after transplant.Importantly, elevated IgE was not associated with any global or organ-specific measures of cGVHD severity or activity or any acute phase reactants.These results suggest that in patients after allo-HSCT with cGVHD, elevated IgE is not a marker of disease or acute inflammation.

Source: American Journal of Hematology

DOI: 10.1002/ajh.24768