Work

Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches

Year: 2017

Type: article

Abstract: The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the potential of this probiotic mixture to regulate immune cell function, by inducing gene expression of toll-like receptors and other immune related molecules. Furthermore, TUNEL assay showed a decrease in the number of apoptotic cells, and this finding was supported by a reduction in pro-apoptotic factors and an increase in anti-apoptotic molecules. The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation.

Source: Scientific Reports

DOI: 10.1038/s41598-017-01322-1

Authors: Giorgia Gioacchini, Giacomo Rossi, Oliana Carnevali

Institutions: Marche Polytechnic University, Università di Camerino, Istituto Nazionale Biostrutture e Biosistemi

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690