Dissecting Shared and Unique Neural Circuitry Underlying Negative Symptoms, Social Cognition, and Functional Outcome in Schizophrenia
Year: 2015
Type: dissertation
Study design: Observational Study
Abstract: Schizophrenia is a devastating illness with significant disability and poor long-term clinical and functional outcome. Negative symptoms and social cognitive impairments are two key symptom domains that affect functional outcome in schizophrenia. This thesis explores the shared and unique neural circuitry related to negative symptoms, social cognition, and functional outcome in schizophrenia. In study one, the relationship between white matter fractional anisotropy, negative symptoms, and functional outcome in schizophrenia participants was investigated. Study two includes a broad sample of patient and healthy control populations, which is in line with the RDoC methodology. In this study, the relationship between white matter tracts implicated in functional outcome and social cognitive domains was investigated in a sample of schizophrenia, bipolar disorder, and healthy control participants on a continuum of social cognitive performance. Taken together, these studies elucidate circuitry that may be impaired in schizophrenia, and may represent neurobiological correlates of negative symptoms, social cognition, and functional outcome.
Source: TSpace (University of Toronto)
Author: Tina Behdinan
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2610178152