Year: 2017
Type: review
Abstract: Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans. We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford–Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans. The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10−12) atIKZF3. Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block asIKZF3(e.g. ZPBP2,ORMDL3andGSDMB) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 atGSDMB, but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs atIL1RL1,TSLPandGSDMBbut not forIL33. Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.
Source: European Respiratory Journal
Authors: Qi Yan, John Brehm, Maria Pino-Yanes, Erick Forno, Jerome Lin, Sam S. Oh, Edna Acosta-Perez, Cathy C. Laurie, Michelle M. Cloutier, Benjamin A. Raby, Adrienne M. Stilp, Tamar Sofer, Donglei Hu, Scott Huntsman, Celeste S. Eng, Matthew P. Conomos, Deepa Rastogi, Kenneth Rice, Glorisa Canino, Wei Chen, R. Graham Barr, Esteban G. Burchard, Juan C. Celedón
Institutions: University of Pittsburgh, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Universidad de La Laguna, Instituto de Salud Carlos III, Hospital Universitario Nuestra Señora de Candelaria, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, University of California, San Francisco, University of Puerto Rico System, University of Washington, University of Connecticut, UConn Health, Brigham and Women's Hospital, Harvard University, Albert Einstein College of Medicine, Columbia University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Office of Dietary Supplements, Robert Wood Johnson Foundation, Heinz Endowments, Tobacco-Related Disease Research Program, University of Miami, Northwestern University, San Diego State University, Sandler Foundation, University of Washington, American Asthma Foundation, European Commission, National Institutes of Health, Instituto de Salud Carlos III, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities, Children's Hospital of Pittsburgh
Awards: G1004541261, G1042216835, G1081972346, Genetics of Asthma In Latino Americans, G1143783203, G1149719706, G1268573537, G1301356587, G1312369436, G141679577, G1455175283, G1496442913, G1587824183, G1666450717, G1888983140, G1917633662, G2128161193, G2135211244, G2135293100, G2189466114, Addressing disparities in chronic disease with a teen and young adult focus, G2263518244, G2466919156, G2501967490, G2528054427, G2575730562, G2644289446, G2645088300, G28126969, G2878178050, G2970637568, G2989046130, G3062787641, G3208052949, G3303002146, G3429567754, G3653855969, G3677686024, G3838006641, G3868479415, G3908360582, G3952816605, G4015031248, G4121762840, G434337789, G4441691082, Obesity and Asthma Subphenotypes and Underlying Genetic and Genomic Pathways, G454726209, G4552920371, G4752697780, G4841314509, G48492847, G4860668542, G4897104811, G4905463976, G4989378220, G51047235, G5129651400, G5223154479, G528357465, G5365244667, G5397198720, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G5935820280, G5993399974, G6045475270, G6075306088, G6156511736, G6585687856, G6744188800, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G729036485, G7408420985, G7513901258, G7678550560, G7712917536, G8008018803, G8102260223, G820454163, G830324587, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, G9000021036, G9000038401, G9000092064, G9000104403, G9000122063, G9000147790, G9000291987, G9000320998, G9000335557, G954279374
OpenAlex ID: W2610225966