Work

Inhibitory effects of S100A4 gene silencing on alkali burn-induced corneal neovascularization: an in vivo study.

Year: 2017

Type: article

Abstract: OBJECTIVE: gene silencing on alkali burn-induced corneal neovascularization (CNV) in rabbit models. METHODS: , vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) in corneal tissues. Immunohistochemistry was used to detect the protein expression of VEGF in corneal tissues, and an enzyme-linked immunosorbent (ELISA) assay was used to detect the protein expression of VEGF and TNF-α in the aqueous humor. RESULTS: siRNA group in comparison to the empty vector group at 1, 3, 7, 14, and 28 days after an alkali burn. CONCLUSIONS: gene silencing can inhibit alkali burn-induced CNV in rabbits.

Source: PubMed Central

Authors: Yu-Lin Wang, Gui-Ping Gao, Yu-Qin Wang, Ying Wu, Zhi-You Peng, Quan Zhou

Institutions: First Affiliated Hospital of Nanchang University, Affiliated Eye Hospital of Wenzhou Medical College

Language: English

Topic: Corneal Surgery and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Natural Science Foundation of Jiangxi Province

OpenAlex ID: W2610491064

FWCI: 1.067

Cites: 32

Cited by: 8

Related to: 10