ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis
Year: 2017
Type: article
Abstract: reduces the genome binding of RAD21 and SMC1A and alters the expression of ASXL1/cohesin target genes in LK cells. Our study underscores the ASXL1-cohesin interaction as a novel means to maintain normal sister chromatid separation and regulate gene expression in hematopoietic cells.
Source: Science Advances
Authors: Zhaomin Li, Peng Zhang, Aimin Yan, Zhengyu Guo, Yuguang Ban, Jin Li, Shi Chen, Hui Yang, Yongzheng He, Jianping Li, Ying Guo, Wen Zhang, Ehsan Hajiramezanali, Huangda An, Darlene Fajardo, J. William Harbour, Yijun Ruan, Stephen D. Nimer, Peng Yu, Xi Chen, Mingjiang Xu, Feng-Chun Yang
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: Comprehensive Mapping of Long-Range Chromatin Interactions in Human and Mouse Genomes, Characterization of RNA-Chromatin Interactome by RNA-DNA Ligation and Sequencing, Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignancies, No-nonsense approach to treat myeloid malignancies with ASXL1 nonsense mutations, G2010190212, G2766225622, The Genetics of Ocular Melanoma, Workshop on Chromatin Interaction Analysis using Paired-End Tag Sequencing, Nucleome Positioning System for Spatiotemporal Genome Organization and Regulation, G7723948164, G8717385705, Targeted therapy for t(8;21)+ AML, Cancer Center Support (CORE) Grant
OpenAlex ID: W2578906464