Work

Comparison of single- and five-fraction schedules of stereotactic body radiation therapy for central lung tumours: a single institution experience

Year: 2017

Type: article

Abstract: Background Stereotactic body radiation therapy (SBRT) is a treatment option for patients with early-stage non-small cell lung cancer who are medically inoperable or decline surgery. Here we compare the outcome of patients with centrally located lung tumours who underwent either single fraction (SF)- or five-fraction (FF-) SBRT at a single institution over 5 years. Methods Between January 2009 and October 2014, patients with centrally located lung tumours who underwent SBRT were included in this study. Data were retrospectively collected using an institutional review board-approved database. For analysis, the Kaplan–Meier method and competing risks method were used. Results In total, 11 patients received 26–30 Gy in 1 fraction, whereas 31 patients received 50–60 Gy (median 55 Gy) in 5 fractions. After a median follow-up of 12 months for SF-SBRT and 17 months for FF-SBRT groups ( p =0·64), 1-year overall survival rates were 82 and 87%, respectively. SF- and FF-SBRT groups showed no significant difference in grade 3+ toxicity ( p =0·28). The only grade 4 toxicity ( n =1) was reported in the SF-SBRT group. All toxicities occurred >12 months after the SBRT. Conclusions SF- and FF-SBRT have comparable overall survival. SF-SBRT may have some utility for patients unable to have multi-fraction SBRT.

Source: Journal of Radiotherapy in Practice

DOI: 10.1017/s1460396917000061

Authors: Sung Jun Ma, Yusef A. Syed, Charlotte I. Rivers, Jorge A. Gomez Suescun, Anurag K. Singh

Institutions: Roswell Park Comprehensive Cancer Center, University at Buffalo, State University of New York

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550