Year: 2017
Type: article
Abstract: Genome editing in pigs has tremendous practical applications for biomedicine. The advent of genome editing technology, with its use of site-specific nucleases-including ZFNs, TALENs, and the CRISPR/Cas9 system-has popularized targeted zygote genome editing via one-step microinjection in several mammalian species. Here, we review methods to optimize the developmental competence of genome-edited porcine embryos and strategies to improve the zygote genome-editing efficiency in pigs.
DOI: 10.1002/mrd.22829
Language: English
Subfield: Genetics
Domain: Life Sciences
SDG: Zero hunger
Open Access status: bronze
Awards: G1386523576, G4811074209, G4828670277
OpenAlex ID: W2610795892