Work

ILDR1 is important for paracellular water transport and urine concentration mechanism

Year: 2017

Type: article

Abstract: Significance The role of tight junction in water homeostasis is an important but understudied area. Here, we reveal a paracellular water permeation pathway made by the tricellular tight junction and regulated by its integral protein, known as Ildr1. The importance of paracellular water permeation is demonstrated here with emphasis of its potential role in causing urinary concentrating defects in the kidney. Ildr1 and its related proteins, Ildr2 and Ildr3, may play broader physiologic roles to establish the water homeostasis in other organs, such as the skin, the lung, and the intestine.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1701006114