Work

Brønsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Year: 2017

Type: article

Abstract: Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Brønsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

Source: Organic Letters

DOI: 10.1021/acs.orglett.7b00958

Authors: Xiao Cai, Amir Keshavarz, Justin D. Omaque, Benjamin J. Stokes

Institution: University of California, Merced

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: University of California Merced