Identification of Protective B-Cell Epitopes within the Novel Malaria Vaccine Candidate Plasmodium falciparum Schizont Egress Antigen 1
Year: 2017
Type: article
Abstract: ABSTRACT Naturally acquired antibodies to Plasmodium falciparum schizont egress antigen 1 (PfSEA-1A) are associated with protection against severe malaria in children. Vaccination of mice with SEA-1A from Plasmodium berghei (PbSEA-1A) decreases parasitemia and prolongs survival following P. berghei ANKA challenge. To enhance the immunogenicity of PfSEA-1A, we identified five linear B-cell epitopes using peptide microarrays probed with antisera from nonhuman primates vaccinated with recombinant PfSEA-1A (rPfSEA-1A). We evaluated the relationship between epitope-specific antibody levels and protection from parasitemia in a longitudinal treatment-reinfection cohort in western Kenya. Antibodies to three epitopes were associated with 16 to 17% decreased parasitemia over an 18-week high transmission season. We are currently designing immunogens to enhance antibody responses to these three epitopes.
Source: Clinical and Vaccine Immunology
DOI: 10.1128/cvi.00068-17
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: PfSEA-1 based vaccines for falciparum malaria, Immune-Based Interventions Against Infectious Diseases, G2776176526, Targeted Vaccine Development for Pediatric Falciparum Malaria, Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children, Pathogenesis of falciparum malaria in infancy, G9000231091, HIV and Other Infectious Consequences of Substance Use
OpenAlex ID: W2611544565