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Reversal of CNS autoimmunity by induction of oral tolerance to brain antigens mediated by antigen presenting cells of the lamina propria [abstract]

Year: 2010

Type: conference-abstract

Abstract: The phenomenon of oral tolerance is important for inducing non-reactivity to food borne antigens and commensal organisms by the immune system. In this study we have devised a method to induce tolerance to an auto-antigen, myelin oligodendrocyte glycoprotein (MOG), by oral administration of a chimeric immunoglobulin, Ig-MOG. Oral treatments with Ig-MOG ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS).

Source: MOspace Institutional Repository (University of Missouri)

Authors: Jason A. Cascio, Cara Haymaker

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2611733649

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