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The Relation of Illness Perception to Psychological Distress and Physical Symptom Burden in Relapsed/Refractory Chronic Lymphocytic Leukemia

Year: 2014
Type: article
Study design: Observational Study
Abstract: Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia and has no known cure.The course of CLL is atypical, often beginning with indolent disease that may or may not require immediate treatment, followed by repeated cycles of aggressive therapy, stable disease, and relapse.Despite these factors, knowledge of psychological functioning of these patients is limited.The current study examined the relation of illness perception to psychological distress and physical symptom burden in a sample of relapsed/refractory CLL patients (N=147) receiving Ibrutinib.Participants completed measures of illness perception (BIPQ), psychological distress (BDI-II, IES-R, SF-12 MCS) and physical symptom burden (SF-12 PCS, FSI, BPI) at baseline and two-months later.Regression analyses revealed that above and beyond disease relevant variables such as treatment history, age, and comorbidities, baseline illness perception was related to all measures of psychological distress and physical symptom burden at baseline (ps < .05),and all measures except for pain at follow-up (ps < .05).Follow-up analyses indicated that the individual illness perception components of consequences, emotional representation, identity, and illness concern might be particularly relevant to psychological and physical functioning of patients with CLL.Results highlight the critical role of subjective illness perception in the experience of distress and burden from physical symptoms, even among patients with cyclical and relapsing disease.Clinical implications and future directions to develop this line of research are discussed.iii For the patients.
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
OpenAlex ID: W2611862454
FWCI:
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Cited by: 1
Related to: 10