Year: 2012
Type: article
Abstract: Peripheral Arterial Disease (PAD) is a chronic disorder associated with reduced blood flow to the extremities which results in serious complications such as critical limb ischemia, limb amputation and in some cases may lead to death.Approximately 18 million patients in US were affected by PAD in 2010 and with an increasing aging population this number is estimated to increase to 24 million by 2030.There is an urgent need for the development of safe and effective novel drug therapies targeting the stimulation of new vessel growth and help in revascularization of ischemic found in PAD.The disease is a result of atherosclerosis and endothelial dysfunction leading to decreased nitric oxide bioavailability, an important modulator of vascular tone.TheraVasc has come up with a novel pharmaceutical composition TV1001 that is a nitric oxide prodrug and enhances nitric oxide bioavailability in ischemic region of limbs associated with PAD.TV1001 induces angiogenesis and enhances tissue perfusion specifically in ischemic tissue.
Author: Neeti Maan
Institution: Case Western Reserve University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2612399805