Anxiety in Chronic Moderate to Severe Traumatic Brain Injury: Measurement and Relation to Hippocampal Volume Loss
Year: 2015
Type: dissertation
Study design: Observational Study
Abstract: Moderate to severe traumatic brain injury (TBI) can result in chronic and progressive atrophy of the hippocampus (HPC), a bilateral brain structure housed in the medial temporal lobes. As demonstrated in a recent study of individuals with amnestic Mild Cognitive Impairment and early Alzheimer’s disease, anxiety is a candidate mechanism underlying atrophy of the medial temporal lobes in neurological populations. This thesis investigates (1) the validity of the Beck Anxiety Inventory (BAI) for measuring anxiety in chronic TBI and (2) the role of anxiety in HPC volume loss in this population. First, evidence for the validity of the BAI in chronic TBI is provided. Second, it is shown that higher anxiety on the BAI at 5 and 12 months post-injury predicts subsequent atrophy of the right HPC complex, particularly of the right HPC head.
Source: TSpace (University of Toronto)
Author: Terpstra, Alexander Roy
Institution: University of Toronto
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2612410932