Work

The condensin complex is a mechanochemical motor that translocates along DNA

Year: 2017

Type: article

Abstract: Condensin is a highly processive DNA motor Condensin is thought to regulate genome architecture by creating DNA loops. Terakawa et al. used single-molecule imaging to show that yeast condensin is a highly processive mechanochemical motor capable of translocating along DNA (see the Perspective by Nasmyth). Their findings elucidate how the rapid ATP hydrolysis–dependent motor activity of condensin provides the driving forces necessary to support three-dimensional chromosome organization and compaction through a loop extrusion mechanism. Science , this issue p. 672 ; see also p. 589

Source: Science

DOI: 10.1126/science.aan6516

Authors: Tsuyoshi Terekawa, Shveta Bisht, Jorine M. Eeftens, Cees Dekker, Christian H. Haering, Eric C. Greene

Institutions: Columbia University, European Molecular Biology Laboratory, European Molecular Biology Laboratory, Delft University of Technology

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green