Work

ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin

Year: 2016

Type: article

Abstract: signalling and embryonic development. ADP-ribosyl cyclase isoforms (SpARC1-4) showed unique changes in expression during early development. These changes were associated with an increase in the ratio of cADPR:NAADP production. Over-expression of SpARC4 (a preferential cyclase) disrupted gastrulation. Our data highlight the importance of ADP-ribosyl cyclases during embryogenesis.

Source: Messenger

DOI: 10.1166/msr.2016.1052

Authors: Latha Ramakrishnan, Kevin Uhlinger, Leslie Dale, Amro Hamdoun, Sandip Patel

Institutions: University College London, Scripps Institution of Oceanography, University of California San Diego

Language: English

Topic: Calcium signaling and nucleotide metabolism

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Biotechnology and Biological Sciences Research Council, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Membrane contact sites between endolysosomes and the ER as novel hubs in Ca2+ signalling., Control of Multidrug Transport Activity in Embryos, Control of efflux transporter activity by cell surface reorganization in embryos., Molecular and Functional Characterisation of Sea Urchin ADP-ribosyl Cyclases, A role for a novel animal endo-lysosomal Ca2+/H+ exchanger in Ca2+ signalling and chemotaxis.