Maximizing the max test: Development of a maximal graded exercise test for the assessment of cardiovascular function in mice
Year: 2015
Type: article
Abstract: Tools for the functional assessment of cardiovascular fitness are needed to establish animal models of dysfunction and the effects of novel therapeutics.Currently, exercise assays are widely published; however, they have limited sensitivity for assessing the cardio-metabolic phenotype of mice.In human research, the graded maximal exercise test (GXT) is a gold standard diagnostic for measuring cardiovascular function.Present published testing methods in mice use set inclination and progressive increases in speed until exhaustion (PXT); thus lacking characteristics of the GXT.We developed a GXT test that allows for assessment of cardiovascular fitness in metabolic and genetic models of cardiovascular dysfunction; as well as in healthy mice.The results of comparison between this method and the PXT revealed that only the GXT test provides sensitive, quantitative, parameters for diagnosing and monitoring cardiovascular, metabolic and pulmonary function in mouse models.
Author: Jennifer M. Petrosino
Institution: The Ohio State University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2612777969