Work

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Year: 2017

Type: article

Source: Nature

DOI: 10.1038/nature22344

Authors: Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Wenjian Gan, Jianping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun, Wenyi Wei

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Army Medical University, Daping Hospital, The University of Texas MD Anderson Cancer Center, Southwest Hospital, Beijing Proteome Research Center, State Key Laboratory of Proteomics

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G1689724940, G1867594068, Regulation of T-cell function and autoimmune inflammation by deubiquitinases., G3084427372, G311021743, G3355947620, Mechanisms of Selective Autophagy, G4248382729, Novel regulation of PI3K/Akt to direct targeted breast cancer therapies, Interplay between Cdh1 and major regulatory pathways in human cancer, Targeting the APC/Cdc20 E3 ubiquitin ligase for chemoradiation sensitization, G9000071702, G9000204335

OpenAlex ID: W2612937617

FWCI: 6.89

Cites: 46

Cited by: 194

Related to: 10