Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis
Year: 2017
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). CONCLUSIONS Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.
Authors: Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Tong Liu, Mohammadreza Lotfaliani, Michel Pompeu Barros de Oliveira Sá, William L. L. Baker, Senol Yavuz, Mohamed Zeriouh, Jae-Sik Jang, Hamidreza Dehghan, Lei Meng, Luca Testa, Fabrizio D\'Ascenzo, Umberto Benedetto, Gary Tse, Luis Nombela-Franco, Pascal M. Dohmen, Abhishek J. Deshmukh, Cecilia Linde, Giuseppe Biondi-Zoccai, Gregg W. Stone, Hugh Calkins, Integrated Meta-Analysis of Cardiac Surgery and Cardiology-Group [IMCSC-Group]
Institutions: Carl von Ossietzky Universität Oldenburg, Shahid Sadoughi University of Medical Sciences and Health Services, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Second Hospital of Tianjin Medical University, Tianjin Medical University, Hartford Hospital, University of Connecticut, S.B.Ü. Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Inje University, Inje University Busan Paik Hospital, IRCCS Policlinico San Donato, University of Turin, University of Bristol, Chinese University of Hong Kong, Hospital Clínico San Carlos, Mayo Clinic, Karolinska University Hospital, Karolinska Institutet, Sapienza University of Rome, NewYork–Presbyterian Hospital, Columbia University Irving Medical Center, Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2613045934