Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
Year: 2017
Type: article
Study design: Observational Study
Abstract: Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of colorectal cancer with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2140 histologically-confirmed incident colorectal cancer cases and 4098 population-based controls were recruited. Controls were frequency-matched by sex, age and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1488 cases and 2495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ≥4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: H. pylori seropositivity was not associated with increased colorectal cancer risk (OR=0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagδ showed a lower colorectal cancer risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher colorectal cancer risk. A possible effect modification by age and sex was identified.
Source: Frontiers in Microbiology
Authors: Nerea Fernández de Larrea-Baz, Angelika Michel, Beatriz Romero, Beatriz Pérez-Gómez, Victor Moreno, Vicente Martín, Trinidad Dierssen-Sotos, José J. Jiménez-Moleón, Jesús Castilla, Adonina Tardón, Irune Ruiz, Rosana Peiró, Antonio Tejada, María D. Chirlaque, Julia A. Butt, Rocío Olmedo-Requena, Inés Gómez-Acebo, Pedro Linares, Elena Boldo, Antoni Castells, Michael Pawlita, Gemma Castaño-Vinyals, Manolis Kogevinas, Silvia de Sanjosé, Marina Pollán, Rosa del Campo, Tim Waterboer, Nuria Aragonés
Institutions: Instituto de Salud Carlos III, Centro Nacional de Epidemiología, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, German Cancer Research Center, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Universidad de León, Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Instituto de Salud Pública de Navarra, Universidad de Oviedo, Donostiako Unibertsitate Ospitalea, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universidad de Huelva, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Complejo Asistencial Universitario de León, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat Pompeu Fabra, Center for Research in Environmental Epidemiology, Hospital Del Mar, Municipal Institute for Medical Research, Barcelona Institute for Global Health, Hospital del Mar Research Institute, Red Espanola de Investigacion en Patologia Infecciosa
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G137056171, G1418927621, G1563087297, G2517447667, G2620658983, G2794027481, G2929754249, G2952780389, G3559709381, G3635063837, G3771020718, G3931208633, Identificación de marcadores de susceptibilidad genética útiles para el diseño de estrategias personalizadas de cribado, G451885579, G4540457744, G5716438915, G640610580, G7349428362, Integración de big data genéticos y datos clínicos: supervivencia con cáncer de mama en el estudio MCC-Spain, G8190793960, G8759146715, Perfil molecular del envejecimiento en la patogénesis y pronóstico de la leucemia linfática crónica, G994301069
OpenAlex ID: W2613197367