Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies
Year: 2017
Type: article
Abstract: Whether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown. We analyzed the interactions between genetic predisposition and habitual coffee consumption in relation to BMI and obesity risk in 5116 men from the Health Professionals Follow-up Study (HPFS), in 9841 women from the Nurses’ Health Study (NHS), and in 5648 women from the Women’s Health Initiative (WHI). The genetic risk score was calculated based on 77 BMI-associated loci. Coffee consumption was examined prospectively in relation to BMI. The genetic association with BMI was attenuated among participants with higher consumption of coffee than among those with lower consumption in the HPFS (P interaction = 0.023) and NHS (P interaction = 0.039); similar results were replicated in the WHI (P interaction = 0.044). In the combined data of all cohorts, differences in BMI per increment of 10-risk allele were 1.38 (standard error (SE), 0.28), 1.02 (SE, 0.10), and 0.95 (SE, 0.12) kg/m2 for coffee consumption of < 1, 1–3 and > 3 cup(s)/day, respectively (P interaction < 0.001). Such interaction was partly due to slightly higher BMI with higher coffee consumption among participants at lower genetic risk and slightly lower BMI with higher coffee consumption among those at higher genetic risk. Each increment of 10-risk allele was associated with 78% (95% confidence interval (CI), 59–99%), 48% (95% CI, 36–62%), and 43% (95% CI, 28–59%) increased risk for obesity across these subgroups of coffee consumption (P interaction = 0.008). From another perspective, differences in BMI per increment of 1 cup/day coffee consumption were 0.02 (SE, 0.09), –0.02 (SE, 0.04), and –0.14 (SE, 0.04) kg/m2 across tertiles of the genetic risk score. Higher coffee consumption might attenuate the genetic associations with BMI and obesity risk, and individuals with greater genetic predisposition to obesity appeared to have lower BMI associated with higher coffee consumption.
Source: BMC Medicine
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funders: Foundation for the National Institutes of Health, U.S. Department of Health and Human Services, American Heart Association, United States-Israel Binational Science Foundation, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Eye Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota, Obesity Genes, Energy Regulation in Response to Weight-Loss Diets, G1947136479, Genetic Markers of CHD in Type 2 Diabetes, Dietary And Lifestyle Determinants Of Colon Cancer Recurrence and Survival, G2273349799, G2412562481, Biochemical Markers in the nurses' Health Study Cohort, Gene-Environment Interactions in Glaucoma, G3196836363, G3545534745, G3910262014, G412187901, Genes and Environment Initiative in Glaucoma, G459566519, Common Genetic Variation and Quantitative Diabetes Traits, G5547620395, G5624510383, Genome-wide interactions with diet patterns on long-term weight change, Rare Sequence Variation and Diabetes Quantitative Traits, G619791618, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Biochemical Markers in the Nurses? Health Study Cohort, Cancer Epidemiology Cohort in Male Health Professionals, G8115171704, G8536616440, G8872617512, NEIGHBORHOOD Consortium for POAG Genetics, Yale Clinical and Translational Science Award, RISK FACTORS FOR CVD IN WOMEN
OpenAlex ID: W2613965594