MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
Year: 2017
Type: article
Abstract: Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.
Source: Stem Cell Reports
Institutions: Brigham and Women's Hospital, Harvard University, Broad Institute, Dana-Farber Cancer Institute, Massachusetts Institute of Technology, University Medical Center Hamburg-Eppendorf, Mossakowski Medical Research Institute, Polish Academy of Sciences, Polish Academy of Sciences, University of Alabama at Birmingham, UAB Medicine, Massachusetts General Hospital, Center for Systems Biology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funder: National Cancer Institute
OpenAlex ID: W2614567943