Work

Genetically engineered mouse models of melanoma

Year: 2017

Type: review

Abstract: Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103. © 2017 American Cancer Society.

Source: Cancer

DOI: 10.1002/cncr.30684

Authors: Eva Pérez‐Guijarro, Chi‐Ping Day, Glenn Merlino, M. Raza Zaidi

Institutions: National Institutes of Health, National Cancer Institute, Temple University

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute