Work

Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl–prolyl isomerase Pin1

Year: 2017

Type: article

Abstract: Cyclic peptides are capable of binding and modulating challenging drug targets including protein-protein interactions. However, their lack of membrane permeability prevents their application against intracellular targets. In this study, we show that it is possible to design a cell-permeable and biologically active cycloheptapeptide inhibitor against the intracellular enzyme peptidyl-prolyl isomerase Pin1 by integrating cell-penetrating and target-binding sequences.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c7ob00430c

Authors: Walaa Bedewy, Hui Liao, Nageh A. Abou-Taleb, Sherif F. Hammad, Tamer Nasr, Dehua Pei

Institutions: The Ohio State University, Helwan University

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences