Effect of Zoledronic Acid on Maxillary Alveolar Bone Coverage in Rice Rats With and Without Dental Trauma
Year: 2013
Type: article
Abstract: Bisphosphonates are a class of drug widely used in both human and veterinary medicine for the treatment of pathologies affecting bone remodeling.Currently they represent the most commonly prescribed therapy for osteoporosis, with over 5 million prescriptions filled in the United States every year.Over the last decade the use of high dose nitrogen-containing bisphosphonates (BPs) has become increasingly popular in the multimodal approach to oncologic conditions.This class of medication has been shown to slow the progression of certain tumor cells from penetrating healthy bone tissues as well as slowing tumor cell proliferation.In addition BPs have been shown to significantly reduce the discomfort associated with metastases in some patients.Unfortunately, as the use and dosing of BPs has increased, so has the clinical complication associated with their use.Most notably, a condition known as bisphosphonate related osteonecrosis of the jaw (BRONJ) has emerged over the last ten years.While this condition has been linked to multiple risk factors, high dose BP usage and trauma in the oral cavity have been shown to be the primary events that precede the development of BRONJ lesions.BRONJ is a disabling and painful condition affecting both the maxilla and mandible.To date this condition is poorly understood, and consequently current treatment options are inconsistently effective.
Author: Jason Callard
Institution: The Ohio State University
Language: English
Topic: Bone health and treatments
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2615505159