Interfascicular Interfaces for Peripheral Nerve Stimulation: Directed Stimulation within the Epineurial Space
Year: 2013
Type: article
Abstract: Computational models have shown that directional electrical contacts placed within the epineurium, between the fascicles, and not penetrating the perineurium can achieve selectivity levels similar to point source contacts placed within the fascicle.The reported study tests the hypothesis that directed interfascicular contacts are selective.Multiple interfascicular electrodes with directional contacts, exposed on a single face, were implanted in the sciatic nerves of thirty two rabbits.Fine-wire intramuscular wire electrodes were implanted to measure electromyographic (EMG) activity from medial and lateral gastrocnemius, soleus and tibialis anterior muscles.The recruitment data demonstrated that directed interfascicular interfaces can selectively activate different axon populations, without penetrating the perineurium.
Author: Smruta Koppaka
Institution: Case Western Reserve University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2615895701