Short duration of antibiotic therapy in hospitalized patients with community-acquired pneumonia: results from the CAPO International Cohort Study
Year: 2017
Type: article
Abstract: Introduction: Experts suggest a short duration of antibiotic therapy (DOT) in responding patients with community-acquired pneumonia (CAP). The aim of this study was to evaluate clinical outcomes after hospital discharge among patients treated with short-course antibiotic therapy (SCT) vs. long-course antibiotic therapy (LCT) for CAP. Methods: A secondary analysis of the Community-Acquired Pneumonia Organization (CAPO) database from January 2007 to June 2013 was performed, including hospitalized CAP patients who reached clinical stability within 5 days. Two groups were identified: patients who were treated with antibiotic therapy for a total duration of 5 days or less (SCT Group) vs. longer than 5 days (LCT Group). Rehospitalization and mortality were evaluated at 30 days after discharge. Results: 1,849 patients were enrolled (58% males; median age: 65 years), 179 (10%) were included in the SCT and 1,670 (90%) in the LTC group. Median DOT was 5 days in the SCT and 10 days in the LTC group, p Conclusions: A duration of antibiotic therapy of ≤ 5 days does not adversely impact clinical outcomes at 30-days after discharge compared to >5 days in patients who reached early clinical stability.
Institutions: University of Louisville, The University of Texas at San Antonio Health Science Center, University of Dundee, University of Milan, Universidad de Buenos Aires, Ninewells Hospital, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, South Texas Veterans Health Care System, University of Milano-Bicocca
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2616039666