Correlating Innate Functional Recovery from Stroke Either with Stem Cell Proliferation and/or Limb Rehabilitation
Year: 2016
Type: article
Abstract: In the present study 10-12 month female rats were examined for functional recovery from stroke and this recovery was compared with the stem cell/progenitor cell proliferation in the brain (which was measured by Ki67). The cell proliferation indicated by Ki67 showed a 6 fold increase in control animals compared to the rehabilitation animals. The contralateral functional recovery in control animals were 46.6% and in the rehabilitation animals were 24.5%. The physical rehabilitation was carried out to determine if limb rehabilitation can promote greater functional recovery. The results showed that when the animals were made to over use their impaired limb compared to non-impaired limb, they experienced physical stress that decreased the stem cell/progenitor cell proliferation in the subventricular zone. This is the first study which shows that increased physical stress (due to voluntary exercise) will decrease the Ki67 levels in the subventricular zone in animals after ischemic stroke.
Author: Devipriyanka Nagarajan
Institution: Wright State University
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2618203276