Work

Blast Scaling Parameters: Transitioning from Lung to Skull Base Metrics.

Year: 2017

Type: article

Abstract: Neurotrauma from blast exposure is one of the single most characteristic injuries of modern warfare. Understanding blast traumatic brain injury is critical for developing new treatment options for warfighters and civilians exposed to improvised explosive devices. Unfortunately, the pre-clinical models that are widely utilized to investigate blast exposure are based on archaic lung based parameters developed in the early 20th century. Improvised explosive devices produce a different type of injury paradigm than the typical mortar explosion. Protective equipment for the chest cavity has also improved over the past 100 years. In order to improve treatments, it is imperative to develop models that are based more on skull-based parameters. In this mini-review, we discuss the important anatomical and biochemical features necessary to develop a skull-based model.

Source: PubMed

Authors: Brandon P Lucke-Wold, Ryan C Turner, Aric Flint Logsdon, Charles L Rosen, Rabia Qaiser

Institutions: West Virginia University, University of Washington

Language: English

Topic: Automotive and Human Injury Biomechanics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of General Medical Sciences

Awards: Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's Disease, West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health