Work

The missing, the short, and the long: Levodopa responses and dopamine actions

Year: 2017

Type: review

Abstract: We attempt to correlate the clinical pharmacology of dopamine replacement therapy (DRT) in Parkinson Disease with known features of striatal dopamine actions. Despite its obvious impact, DRT does not normalize motor function, likely due to disrupted phasic dopaminergic signaling. The DRT Short Duration Response is likely a permissive-paracrine effect, possibly resulting from dopaminergic support of corticostriate synaptic plasticity. The DRT Long Duration Response may result from mimicry of tonic dopamine signaling regulation of movement vigor. Our understanding of dopamine actions does not explain important aspects of DRT clinical pharmacology. Reducing these knowledge gaps provides opportunities to improve understanding of dopamine actions and symptomatic treatment of Parkinson disease.

Source: Annals of Neurology

DOI: 10.1002/ana.24961

Authors: Roger L. Albin, Daniel K. Leventhal

Institutions: University of Michigan, VA Ann Arbor Healthcare System, Michigan Medicine, Ann Arbor VA Medical Center

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Michael J. Fox Foundation for Parkinson's Research, National Institutes of Health, National Institute of Neurological Disorders and Stroke