Mp404association Between Extent of Myocardial Fibrosis Assessed by Native T1 Mapping Cardiac Magnetic Resonance and Biomarkers and the Level of Estimated Glomerular Filtration Rate
Year: 2017
Type: conference-abstract
Abstract: INTRODUCTION AND AIMS: Cardiac structural changes in patients with kidney disease are often asymptomatic and portend poor prognosis. This study aims to evaluate the association between GFR and myocardial fibrosis as assessed by native T1 mapping cardiac magnetic resonance imaging (MRI) and circulating levels of cardiac biomarkers. METHODS: We performed native T1 mapping cardiac MRI in 22 incident patients with eGFR above 90 ml/min/1.73m2 (n=5), 30-60 ml/min/1.73m2 (n=10), 15-29 ml/min/1.73m2 (n=6) and below 15 ml/min/1.73m2 (n=1). Native T1 cardiac MRI relaxation times and cardiac biomarkers of fibrosis (galectin 3) and myocardial stretching (ST2) were analyzed and correlated with eGFR. RESULTS: Global T1 mapping time progressively increased with eGFR decline (1016 ± 40 ms; 1035 ± 50 ms; 1037 ±50 ms; and 1101± 43 ms, for eGFR more than 90; 30-60; 15-29; and less than 15 ml/min/1.73m2 respectively (p=0.03 between groups). Similar inverse correlation was found between eGFR and galectin 3 (R = - 0.79) and ST2 levels (R = - 0.32). CONCLUSIONS: There is a graded association between eGFR and myocardial fibrosis, with higher indices of fibrosis found at lower levels of eGFR. Noninvasive quantification of myocardial fibrosis can assist in diagnosis and risk stratification of CKD patients with subclinical heart disease.
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2619172486