Work

Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling

Year: 2017

Type: review

Abstract: Inositol pyrophosphates are small, diffusible signaling molecules that possess the most concentrated three-dimensional array of phosphate groups in Nature; up to eight phosphates are crammed around a six-carbon inositol ring. This review discusses the physico-chemical properties of these unique molecules, and their mechanisms of action. Also provided is information on the enzymes that regulate the levels and hence the signaling properties of these molecules. This review pursues the idea that many of the biological effects of inositol pyrophosphates can be rationalized by their actions at the interface of cell signaling and metabolism that is essential to cellular and organismal homeostasis.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.26017

Author: Stephen B. Shears

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Environmental Health Sciences

Award: Inositol Signalling