Year: 2017
Type: article
Abstract: We report here on the covalent conversion of the anti-inflammatory agent ketoprofen into self-assembling prodrugs that enable the effective purification of ketoprofen enantiomers, the improved selectivity and potency of ketoprofen, as well as the formation of one-component drug-bearing supramolecular hydrogels. We found that the ketoprofen hydrogelator could exhibit much-enhanced selectivity for cyclooxygenase 2 (COX-2) over COX-1, reduce the concentration of inflammatory cytokines (IL-1 and TNFα), and induce apoptosis in fibroblast-like synoviocytes while maintaining biocompatibility with healthy chondrocytes. In addition, these anti-inflammatory agent-containing hydrogels demonstrated the ability to retain the therapeutic within a joint cavity after intra-articular injection, exhibiting a slow, steady release into the plasma. We believe that upon further optimization these drug-based injectable supramolecular hydrogels could provide the basis for a local treatment strategy for rheumatoid arthritis and similar conditions.
Source: Theranostics
DOI: 10.7150/thno.19404
Authors: Zhipeng Chen, Lei Xing, Qin Fan, Andrew G. Cheetham, Ran Lin, Barbara Holt, Liwen Chen, Yanyu Xiao, Honggang Cui
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,671
Funders: National Science Foundation, National Natural Science Foundation of China, Government of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing University, Six Talent Peaks Project in Jiangsu Province, Priority Academic Program Development of Jiangsu Higher Education Institutions, Division of Materials Research
OpenAlex ID: W2619399241