Work

Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G 1 /S phase transition

Year: 2017

Type: article

Abstract: Breaking down miRNAs Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the RNA-induced silencing complex. Tudor-SN targets miRNAs at CA and UA dinucleotides located more than five nucleotides from miRNA ends. Tudor-SN-mediated miRNA decay removes miRNAs that silence genes encoding proteins that are critical for the G 1 -to-S phase transition in the cell cycle. Science , this issue p. 859

Source: Science

DOI: 10.1126/science.aai9372

Authors: Reyad A. Elbarbary, Keita Miyoshi, Jason R. Myers, Peicheng Du, John M. Ashton, Bin Tian, Lynne E. Maquat

Institutions: University of Rochester Medicine, University of Rochester, Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Uehara Memorial Foundation, Mochida Memorial Foundation for Medical and Pharmaceutical Research, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Regulation of Normal and Defective Human Genes, Acquisition of a Typhoon FLA 9500 Laser Scanning Imager, The University of Rochester Core Center for Musculoskeletal Biology and Medicine, G3088386745, G3561444248, Illumina NextSeq500 DNA Sequencing System, G6263161610, Regulation of alternative cleavage and polyadenylation, G9000036175, G9000179029

OpenAlex ID: W2619678069

FWCI: 3.675

Cites: 33

Cited by: 108

Related to: 10