Work

HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in CETP, ABCA1, APOC3, and GALNT2

Year: 2017

Type: article

Abstract: // Mingxuan Cui 1 , Wei Li 1 , Liangkun Ma 2 , Fan Ping 1 , Juntao Liu 2 , Xueyan Wu 1 , Jiangfeng Mao 1 , Xi Wang 1 and Min Nie 1 1 Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Key Laboratory of Endocrine, National Health and Family Planning Commission, Beijing, China 2 Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Correspondence to: Min Nie, email: [email protected] Keywords: high-density lipoprotein-cholesterol, pregnancy, polymorphisms, miRNA-binding site polymorphisms, HDL-C-related genes Received: November 23, 2016 Accepted: April 25, 2017 Published: May 24, 2017 ABSTRACT Objective: To investigate whether HDL-C level in pregnant Chinese Han women of late second trimester correlated with loci in high-density lipoprotein-cholesterol (HDL-C)-related genes found in genome-wide association studies (GWAS). Methods: Seven single-nucleotide polymorphisms (rs3764261 in CETP , rs1532085 in LIPC , rs7241918 in LIPG , rs1883025 in ABCA1 , rs4225 in APOC3 , rs1059611 in LPL , and rs16851339 in GALNT2 ) were genotyped using the Sequenom MassArray system for 1,884 pregnant women. Results: The following polymorphisms were statistically associated with HDL-C level after adjusting for age, gestational week, pre-pregnancy BMI and state of GDM or HOMAIR: (i) rs3764261 (b = -0.055 mmol/L, 95% CI -0.101 to -0.008, p = 0.021), (ii) rs1883025 (b = -0.054 mmol/L, 95% CI -0.097 to -0.012, p = 0.013), (iii) rs4225 (b = -0.071 mmol/L, 95% CI -0.116 to -0.027, p = 1.79E-3) and (iv) rs16851339 (b = -0.064 mmol/L, 95% CI -0.120 to -0.008, p = 0.025). The more risk alleles the pregnant women have, the lower the plasma HDL-C levels of the subjects are. Conclusions: Several risk alleles found to be related to HDL-C in GWAS are also associated with HDL-C levels in pregnant Chinese Han women and these risk loci contribute additively to low HDL-C levels.

Source: Oncotarget

DOI: 10.18632/oncotarget.18128