Year: 2017
Type: article
Abstract: The endocrine system is crucial for maintaining whole-body homeostasis.Little is known regarding endocrine hormones secreted by the heart other than atrial/brain natriuretic peptides discovered over 30 years ago.Here, we identify growth differentiation factor 15 (GDF15) as a heart-derived hormone that regulates body growth.We show that pediatric heart disease induces GDF15 synthesis and secretion by cardiomyocytes.Circulating GDF15 in turn acts on the liver to inhibit growth hormone (GH) signaling and body growth.We demonstrate that blocking cardiomyocyte production of GDF15 normalizes circulating GDF15 level and restores liver GH signaling, establishing GDF15 as a bona fide heart-derived hormone that regulates pediatric body growth.Importantly, plasma GDF15 is further increased in children with concomitant heart disease and failure to thrive (FTT).Together these studies reveal a new endocrine mechanism by which the heart coordinates cardiac function and body growth.Our results also provide a potential mechanism for the well-established clinical observation that children with heart diseases often develop FTT.
Source: EMBO Molecular Medicine
Authors: Ting Wang, Jian Liu, Caitlin McDonald, Katherine Lupino, Xiandun Zhai, Benjamin J Wilkins, Hakon Hakonarson, Liming Pei
Language: English
Topic: GDF15 and Related Biomarkers
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $7,990
Awards: Developmental Trajectories of Negative Symptoms in Schizophrenia, G2281631173, Role of Cirhin/Utp4 in biliary development and disease, POWERING UP MITICHONDRIAL FUNCTIONS TO TREAT MITOCHONDRIAL DISEASE, Coordinated regulation of mitochondrial and cellular functions by nuclear receptors, The Future of Genomics Medicine in Patient Care: Contributions from CHOP, G9000088184, G9000232846, University of Pennsylvania Diabetes Research Center
OpenAlex ID: W2620648363