Year: 2013
Type: dissertation
Study design: Observational Study
Abstract: The objective of this thesis was to determine the association of leg length (LL), a marker of early childhood conditions, with metabolic abnormalities underlying type 2 diabetes. Utilizing data from a population at-risk for diabetes, the associations of LL with i) insulin\nresistance (IR) and beta-cell dysfunction and ii) a continuous metabolic syndrome risk score (MetScore) were analyzed. Results showed that shorter LL was associated with IR and beta-cell dysfunction, and that the combination of short legs and large waist (a marker of adult obesogenic conditions) was associated with the greatest IR. Height, a marker of overall childhood conditions, was found to be inversely associated with the MetScore. Therefore, both adverse childhood conditions and early-late life mismatched conditions may increase the risk for diabetes through differing pathways. Improving childhood conditions (i.e.\nnutritionally or economically) may be an important strategy to prevent diabetes.
Source: TSpace (University of Toronto)
Author: Luke Johnston
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2620793605