Year: 2017
Type: article
Abstract: Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), constitute a small population of cells within the tumor that has abilities to self-renew like normal stem cells and initiate tumor development (1). CSCs are believed to be responsible for the development of distant metastasis, chemotherapy resistance, and tumor relapse (2). Understanding the regulatory mechanisms behind unique characteristics and vulnerabilities of CSCs would accelerate the development of new therapeutic strategies to prevent tumor relapse and metastasis. Studies have revealed stemness-associated signaling pathways, such as Wnt, Sonic hedgehog (Shh), and Notch, as potential targets for CSCs (3). Increasing evidence demonstrates that upregulation of proteins involved in lipogenesis is also associated with stem-like properties of breast and colorectal cancer cells (4-6).
Source: Stem Cell Investigation
Authors: Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma
Institution: University of Kansas Medical Center
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G1606951390
OpenAlex ID: W2621051450