Examining the Pediatric Epilepsy Surgery Population: The Prognostic Value of Central Nervous System Comorbidities in Probands and their Families
Year: 2014
Type: article
Study design: Observational Study
Abstract: Objective: To determine prevalence of central nervous system (CNS) comorbidities in pediatric patients undergoing epilepsy surgery and their families, and correlate these findings with longterm seizure outcome.Methods: Parents of children, age 0-17, with epilepsy who received resective surgery at Cincinnati Children's Hospital Medical Center (CCHMC) between January 1, 2007 -June 30, 2012 were invited to participate in the study.A three-generation pedigree of epilepsy and its CNS comorbidities was collected via an online or telephone questionnaire from 52 participants. Surgery outcome classification by the International League Against Epilepsy (ILAE) scale wasabstracted from an existing CCHMC clinical database.Proportions of affected probands and relatives were calculated and compared to the general population rates of individual comorbidities and the probands' seizure outcome classification at their most recent follow-up evaluation.Results: Probands had significantly higher rates of ADHD, anxiety, autism, bipolar disorder, cognitive disability, depression and motor disability than the general population.First degree relatives (FDRs) had significantly higher rates of ADHD, autism, depression, and motor disability, and total relatives had higher rates of depression, epilepsy/seizures, and motor disability.Diagnoses of cognitive disability and autism in probands and autism in FDRs were associated with poorer surgery outcomes.Conclusions: Epilepsy probands and their families have significantly higher rates of CNS comorbidities than the general population.Poorer long-term seizure outcomes following resective surgery were associated with diagnoses of autism or cognitive disability in probands iii and autism in FDRs.Together these data support evidence for a common pathophysiological mechanism between epilepsy and its comorbidities.
Author: Krista J. Qualmann
Institution: University of Cincinnati
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2621529280