Year: 2017
Type: dissertation
Abstract: Efficient delivery of antigenic cargo to APCs is a laborious challenge.Cell penetrating peptides are capable of crossing cell membranes without causing a severe disruption of the phospholipid bilayer and to carry along diverse cargoes such as small drugs and various peptides but also antigen epitopes or nucleic acids encoding antigen epitopes.Hence, cell penetrating peptides possess a unique capability to induce potent T cell responses against infectious and non-infectious diseases.Yet, the potential of cell penetrating peptides for application in vaccine formulations has been largely overseen.In this review we provide a general framework for understanding cell penetrating peptides, their mechanism(s) of action and implications for the usage of cell penetrating peptides in vaccine development.Finally, we discuss novel types of cell penetrating peptides, the characteristics of which may render them particularly well suited for application in vaccines targeting the CD8 cytolytic T cell branch of the immune defense.
Author: Vimal Kumar Udhayakumar
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: European Commission
OpenAlex ID: W2621640177