Work

Roles of p53 in extrinsic factor-induced liver carcinogenesis

Year: 2017

Type: article

Abstract: is one of the most frequently mutated genes in liver cancer. p53 regulates expression of genes involved in cell cycle progression, cell death, and cellular metabolism to avert tumor development due to carcinogens. This review article mainly summarizes extrinsic factors that induce liver cancer and potentially have etiological association with p53, including aflatoxin B1, vinyl chloride, non-alcoholic fatty liver disease, iron overload, and infection of hepatitis viruses.

Source: Hepatoma Research

DOI: 10.20517/2394-5079.2017.07

Authors: Tim Link, Tomoo Iwakuma

Institutions: The University of Texas MD Anderson Cancer Center, Kyushu University, The University of Kansas Cancer Center, University of Kansas Medical Center

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Cancer Institute