Preliminary study integrating CACNA1C rs1006737, hippocampal and amygdala volumes, and peripheral endothelial function in youth with bipolar disorder
Year: 2015
Type: dissertation
Study design: Observational Study
Abstract: Multiple genome wide association studies have identified a bipolar disorder (BD) - risk allele polymorphism (CACNA1C rs1006737). rs1006737 is implicated in neurostructural differences in non-BD carriers. As CACNA1C codes for a protein subunit responsible for endothelial function, we predicted it might serve as a genetic underpinning for both the cardiovascular and neurological phenotypes seen in BD. Fifty adolescents (25 healthy controls, 25 BD) completed genotyping, structural scans, and an endothelial function test [reactive hyperemia index (RHI)]. No gene effects were observed in the amygdala or hippocampus, however healthy carriers of the risk allele showed trending reduced volume in the bilateral hippocampus and amygdala when compared to healthy non-carriers. Furthermore, RHI was non-significantly negatively correlated with left hippocampus volume in HC non-carriers, and a significant gene-RHI interaction was observed in the hippocampus of HC. These findings suggest CACNA1C rs1006737 warrants further study as a potential bridge between BD and vascular dysfunction.
Source: TSpace (University of Toronto)
Author: Xiao Ou
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2621999105