Year: 2015
Type: article
Study design: Observational Study
Abstract: Objective.To examine whether the change in maternal insulin, insulin resistance, and cytokines that occurs in the last trimester is related to infant adiposity at birth in non-diabetic, overweight/obese pregnant women. Subjects.Non-diabetic women with a pregravid body mass index (BMI) of >25, ages 18-40 years, were enrolled in the study at 26 weeks gestation.Women with diabetes, hypertension, or tobacco use were excluded.Methods.At 26 and 37 weeks gestation, maternal serum cytokines (TNF-α, IL-6, adiponectin), glucose and insulin were measured.A 2-hour oral glucose tolerance test (OGTT) using a meal was conducted at 37 weeks in the General Clinical Research Center.Insulin resistance (HOMA-IR, %B) was calculated from fasting glucose and insulin.Infant weight and length were reported by the mother or obtained from the medical record.Indices of adiposity were calculated and included percentiles for weight-for-length (WHO Anthro software), and Ponderal Index (wtkgx 703 / heightm 2 ). Analysis.Predictor variables were change in maternal insulin, HOMA-IR, %B, TNF-α IL-6, and adiponectin from 26-37 weeks; outcome variables were percentiles for infant weight-for-length percentile and Ponderal Index.T-test was used to determine differences in these same maternal variables between categories of infant adiposity, grouped by Ponderal Index percentile and weight for length percentile.Results.Forty-five mother infant dyads, (28% non-Hispanic Black, 21% non-Hispanic White, 51% Latino/Hispanic) were included.Infants at or above the 90th percentile for Ponderal Index comprised 23% of the sample.Maternal variables were not correlated with Ponderal Index or Master's studies and the development of this thesis.Additionally, I am grateful to my committee, Dr. Debra Krummel and Dr. Abigail Peairs, for lending their knowledge and experience to the completion of this work.Specifically, Dr. Krummel
Author: Allison E Baker-Kuhn
Institution: University of Cincinnati
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2622232617