Implementation and Application of a Method for Measuring Traction Forces to Characterize Deficient CNP Signaling in Mouse Fibroblasts
Year: 2014
Type: dissertation
Abstract: Adherent cells respond to changes in their microenvironment by generating internal forces that are transferred to the substrate to which they are attached. Manipulation of cellular signaling pathways also influences the response to these changes and can direct cells to pathological outcomes. C-type natriuretic peptide (CNP), through the NPR-B receptor, has been shown to protect quiescent fibroblasts in heart valves from differentiating into myofibroblasts that contribute to development of calcific aortic valve disease (CAVD). Here, I implemented and validated a method for quantifying cellular traction forces
Source: TSpace (University of Toronto)
Author: King Keung Richard Tam
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2622248706