Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia
Year: 2017
Type: article
Study design: Observational Study
Abstract: In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l−1 in non-pregnant females and < 130 g.l−1 in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating total hemoglobin mass considered as a cause. But does this matter? We explored this issue in patients, measuring hemoglobin concentration, total hemoglobin mass (optimized carbon monoxide rebreathing method) and thereby calculating plasma volume in healthy volunteers, surgical patients, and those with inflammatory bowel disease, chronic liver disease or heart failure. We studied 109 participants. Hemoglobin mass correlated well with its concentration in the healthy, surgical and inflammatory bowel disease groups (r=0.687–0.871, P
Source: Haematologica
Institutions: University College London, University Hospital Southampton NHS Foundation Trust, National Institute for Health and Care Research, NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton, Cardiff Metropolitan University, University of Bayreuth, UCL Biomedical Research Centre
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,055
OpenAlex ID: W2622357367