Work

Stimuli-responsive nucleic acid-functionalized metal–organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks

Year: 2017

Type: article

Abstract: -triggered doxorubicin-loaded NMOFs reveal selective cytotoxicity toward MDA-MB-231 cancer cells. Beyond the use of the metal-ion-dependent DNAzymes as ion-responsive locks of drug-loaded NMOF carriers, the DNAzyme-capped fluorophore-loaded NMOFs are successfully applied as functional units for multiplexed ion-sensing and for the design of logic-gate systems.

Source: Chemical Science

DOI: 10.1039/c7sc01765k

Authors: Wei-Hai Chen, Xu Yu, Alessandro Cecconello, Yang Sung Sohn, Rachel Nechushtai, Itamar Willner

Institution: Hebrew University of Jerusalem

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Israel Cancer Association

OpenAlex ID: W2622693495

FWCI: 9.164

Cites: 53

Cited by: 216

Related to: 10