Work

Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons

Year: 2017

Type: article

Abstract: Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the "nil" value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofx055

Authors: Rachel Sparks, David M. Koelle, Joshua E. Stern, Shireesha Dhanireddy

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053