Work

Optical coherence tomography and visual evoked potentials in pediatric MS

Year: 2017

Type: article

Abstract: OBJECTIVE: To determine the relative ability of optical coherence tomography (OCT) and pattern-reversal visual evoked potentials (pVEPs) to detect visual pathway involvement in pediatric-onset MS. METHODS: Pediatric-onset MS participants (onset <18 years) and healthy controls (HCs) underwent OCT (Cirrus HD-OCT) and pVEPs. Retinal nerve fiber layer (RNFL), ganglion cell layer to inner plexiform layer (GCL-IPL), and P100 pVEP latency were measured. Generalized estimating equation models were used to compare the groups, adjusting for age and intereye correlations. RESULTS: = 0.011), whereas prolonged pVEP latency in children with MS occurred independent of ON history. CONCLUSIONS: OCT and pVEPs provide complementary but distinct insights. OCT is sensitive to retinal changes in the context of clinical ON, whereas pVEPs are useful to detect disseminated lesions of the visual pathway in children with MS.

Source: Neurology Neuroimmunology & Neuroinflammation

DOI: 10.1212/nxi.0000000000000356