Work

Capillary endothelia from two ADPKD patients are polyploidy.

Year: 2016

Type: article

Abstract: Bilateral renal cyst formation is the main feature of autosomal dominant polycystic kidney disease (ADPKD). We and other laboratories have previously shown that cyst-lining epithelia of kidneys from ADPKD patients are characterized by polyploidy. In this report, we show that endothelia from the renal capillary beds of two ADPKD patients are also polyploidy. Spectral karyotyping study further confirms our flow cytometry analyses. We suggest that polyploidy may be used as a potential cellular marker in ADPKD.

Source: PubMed

Authors: Sarmed H Kathem, Wissam A AbouAlaiwi, Xiaolin Zi, Surya M Nauli

Institutions: Chapman University, University of California, Irvine, University of Toledo

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Award: The roles of primary cilia in cardiovascular system